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Patients with serious form of sleep apnea are resting easier thanks to a new implanted device @OSUWexMed.  
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Meet the Expert

Dr. William Abraham, MD, FACP, FACC, FAHA, FESC, FRCPE

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Small Implant Makes Big Difference In Sleep Apnea

Study: Pacemaker-like device significantly improves sleep, quality of life

(COLUMBUS, Ohio) September 2013 –  If you’re one of the 12 million Americans with sleep apnea, you know how hard it can be to get a good night’s sleep.  Patients have tried everything from breathing strips to overnight CPAP masks to ease their conditions.

Now, there is a new approach.  Doctors have successfully tested an implantable pacemaker-like device to help patients with central sleep apnea, considered the most dangerous form of this sleep disorder.

“Using this device, we’ve been able to reduce the number of central sleep apnea events by nearly 90 percent,” said William Abraham, MD, director of the division of cardiovascular medicine at The Ohio State University Wexner Medical Center.  “The results are remarkable.”

Most people are more familiar with obstructive sleep apnea, where the throat closes during sleep and causes loud snoring.  It is usually treated with a CPAP breathing mask.

But during central sleep apnea, “the signals from the brain that tell your body to breathe simply stop,” said Dr. Abraham.

“Unfortunately, we don’t have any good treatments for these patients,” he said, “but this device may be a promising start.”

To learn more about the device click on the video box to the left.

To read the full press release, “click to read more” link below.









COLUMBUS, Ohio – A small implant being studied for the treatment of central sleep apnea is showing significant promise, according to study results presented by Dr. William Abraham, director of the Division of Cardiovascular Medicine at The Ohio State University Wexner Medical Center, during today’s Late Breaking Clinical Trials session of the Heart Failure Society of America’s Annual Scientific Meeting.

“Central sleep apnea affects more than a third of heart failure patients and is known to make the condition worse,” Abraham said. “Unfortunately, we don’t have good treatments available for this type of apnea. Currently, positive airway pressure devices are used, but many patients don’t tolerate it well.”

Unlike the more common obstructive sleep apnea, in which the airway gets blocked during sleep and causes pauses in breathing, central sleep apnea is more dangerous because the brain’s signals to tell the body to breathe get interrupted.

“One of the concerning features of  central sleep apnea is that these patients don’t fit the usual profile of obstructive sleep apnea,” said Dr. Rami Khayat, a sleep medicine expert and director of Ohio State’s sleep heart program. “They generally don’t snore, so they’re tougher to diagnose, and the symptoms of sleepiness and fatigue overlap with symptoms associated with heart failure.”

Abraham and other cardiovascular researchers at 11centers around the world tested the feasibility, safety and efficacy of a new transvenous phrenic nerve stimulator made by Respicardia Inc. The device resembles a pacemaker in that it delivers a regular signal to stimulate the diaphragm to breathe during sleep.

In the pilot study, 47 patients were implanted with the device and evaluated for six months. The implant was placed below the collar bone and a transvenous stimulator lead was positioned near the phrenic nerve. After a one-month healing period, the device was turned on and programmed to the patient’s sleep habits.

Researchers saw significant results, including a 56 percent reduction in overall apnea events per hour and more than 80 percent reduction in central sleep apnea events.

"The device normalized breathing during sleep, it reduced apnea episodes and, in association with that, we saw improvements in sleepiness symptoms and patients’ quality of life,” Abraham said. “We also noted a reduction in blood pressure in patients with hypertension.”

Now researchers are comparing the device to current medical therapy for central sleep apnea in a larger randomized, controlled clinical trial. Ohio State’s Wexner Medical Center is again the first in the United States to enroll patients in this research. Once study participants receive the implant, half will have the device turned on soon after surgery, while the control group will wait six months to have their device turned on. Up to 25 centers are participating in this larger randomized trial. Patients will be followed up to five years.

“If these initial findings bear out in the larger studies, an implantable device could be a good option for central sleep apnea patients who cannot tolerate positive airway pressure therapy,” Khayat said.

Along with Abraham and Khayat, Ohio State’s Dr. Ayesha Hasan and Dr. Ralph Augostini are also participating in this study.

The research is being funded by Respicardia. Abraham is a consultant for the company.




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Doctors test new implant for patients with central sleep apnea.
At The Ohio State University Wexner Medical Center, Leslie McGuire was among the first patients in the U.S. to have a pacemaker-like device implanted in his chest to help control central sleep apnea.
Leslie McGuire was one of the first patients in the U.S. To have a device implanted in his chest to help with sleep apnea.
After having a device implanted in his chest to help control his central sleep apnea, at The Ohio State University Wexner Medical Center, Leslie McGuire (left) says he now sleeps through the night and has more energy during the day to spend time with his wife.
Doctors say central sleep apnea can damage the heart.
Doctors at The Ohio State University Wexner Medical Center have successfully tested an implantable device to help patients with central sleep apnea.
Dr. William Abraham is one of the first to test an implantable device to help with symptoms of sleep apnea.
Dr. William Abraham of The Ohio State University Wexner Medical Center says a pacemaker-like device implanted just under a patient`s collar bone can dramatically improve the sleep and quality of life for patients with central sleep apnea.