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Doctors @OSUCCC_James scan DNA to help ID lung cancer & find exact drugs that will work best. Details: bit.ly/197VZxB  
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Greg Otterson, MD


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Machine Helps Smoke-Out Best Lung Cancer Drug

Doctors run 50 DNA tests at once to find best therapy for lung cancer

(COLUMBUS, Ohio) November 2013 – Imagine doctors being able to scan your DNA from a biopsy and pinpoint the medicine that will work best for you. It’s a high-tech approach that scientists at The Ohio State Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute are already using, particularly when it comes to lung cancer, the deadliest form of the cancer in the U.S.

“We get the DNA, put it onto a chip, and we test 50 different genes at once,” said Gregory Otterson, MD an oncologist who specializes in molecular biology and cancer genetics.

“That allows us very quickly to determine which drugs will be effective for your particular cancer, and which won’t,” he said.

That’s especially important in lung cancer because the vast majority of patients are diagnosed in the later stages, meaning it’s important to start effective therapies quickly.

To see how the technology works, click on the video box to the left. To read the full press release, “click to read more” link below.

 

 

 

 

 

 

 

Next-Generation Genome Screening Is Step Toward Precision Cancer Medicine for Lung Cancer

DNA analysis helps doctors identify drugs to more precisely target individual patient tumors

COLUMBUS, Ohio – Precision cancer medicine has taken a strong step forward at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) with the addition of genome screening for lung cancer.

The technology, known as next generation “multiplex” gene sequencing, analyzes 50-plus genes in DNA extracted from a tumor biopsy for particular genetic mutations. Previous technology required pathologists to analyze one mutation per tissue sample. This second-generation genome sequencing assesses more than 2,500 mutations in a single reaction.

Knowing which mutations are present in lung tumors can help oncologists tailor a patient’s treatment to the unique genetic features present in his or her cancer cells. The knowledge can also help in the development of new drugs that target previously unrecognized gene mutations in lung tumors.

Precision Cancer Medicine Driven By DNA

Information from these tests is now critical for determining the most effect therapies, says medical oncologist David Carbone, MD, director of the OSUCCC – James Thoracic Oncology Program. “Tumors that bear certain genetic mutations often respond better to drugs designed to target those mutations than to standard chemotherapy.”

“Each patient’s cancer is genetically distinct, so we must customize our treatments as well,” says Greg Otterson, MD, co-director of the OSUCCC – James Thoracic Oncology Program. “Genomic testing of tumor cells in many cases helps us match a specific patient with the therapy or clinical trial most likely to have a positive effect on his or her cancer.”

“For example, a patient could be given a standard chemotherapy and expect a 35 percent response rate/shrinkage of tumor. But if we know that patient has a mutation in a gene called EGFR, we can offer him a pill (erlotinib), which has a 75 percent response rate -- and fewer side effects,” he adds.

Gene sequencing is now considered the standard of care for stage-4 lung cancer patients at The OSUCCC – James and a handful of other centers across the United States. Several clinical trials evaluating molecular targeted therapies for patients with stage-3 lung cancers will soon at The OSUCCC – James.

“In addition to doing a far better job of finding mutations, this technology is faster, uses patients’ tumor samples efficiently and reduces the cost of genomic testing, making it accessible to more patients,” adds Weiqiang Zhao, MD, PhD, assistant professor of pathology and a member of the OSUCCC – James Molecular Biology and Cancer Genetics Program. Zhao directs the molecular pathology laboratory at The Ohio State University Wexner Medical Center where clinical genome sequencing is performed and analyzed. The lab is accredited by Clinical Laboratory Improvement Amendments (CLIA) for quality.

Lung cancer is the No. 1 cause of cancer death in the United States and the world among both men and women. More than 200,000 cases are diagnosed annually in the United States, and approximately 50 percent of these have metastatic disease at diagnosis, which is generally considered incurable. Although the majority of people with lung cancer have a history of smoking, 15-20 percent of people affected by the disease in the United States have never smoked, and another 40-45 percent have successfully quit smoking.

 

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Images

/newmedia/mcp/osunch/2013/nov13/lungcancer/8-Images/1-Photos/01_chip_closeup.jpg
Tiny DNA chips are giving doctors a huge advantage in battling lung cancer.
This small chip, containing the DNA of eight lung cancer patients, can perform up to 400 genetic tests in one pass. Researchers at The Ohio State University`s James Cancer Hospital and Solove Research Institute and Comprehensive Cancer Center, put a barcode on each patient`s DNA, then use that information to quickly determine which medications will work best for each patient. Details on this remarkable technology here: bit.ly/197VZxB
/newmedia/mcp/osunch/2013/nov13/lungcancer/8-Images/1-Photos/02_tech_chip.jpg
A researcher loads a chip with a patient`s DNA to help determine which cancer drugs will be most effective.
Susan Long, a lead lab technician at The Ohio State University`s James Cancer Hospital and Solove Research Institute and Comprehensive Cancer Center, injects a patient`s DNA onto a computer chip for testing. Doctors take small samples of DNA from lung biopsies and test them for 50 different genetic mutations. The results of the test help doctors quickly decide which medicines will work best for which patients, a huge advantage when battling lung cancer, the deadliest form of cancer in the U.S. Details here: bit.ly/197VZxB
/newmedia/mcp/osunch/2013/nov13/lungcancer/8-Images/1-Photos/03_chip_machine.jpg
High-tech machine conducts 50 DNA tests at once on the tissue of lung cancer patients.
Greg Burton, a lab technician The Ohio State University`s James Cancer Hospital and Solove Research Institute and Comprehensive Cancer Center, loads a chip containing patient DNA into a special machine that can perform 50 genetic tests in one pass. The machine can spot genetic mutations in lung cancer patients, allowing doctors to quickly determine which drugs will be effective and which drugs will not. Details on this remarkable technology here:bit.ly/197VZxB
/newmedia/mcp/osunch/2013/nov13/lungcancer/8-Images/1-Photos/04_machine_closeup.jpg
Machine scans patient`s DNA to find the cancer drugs that will work best.
A high tech machine at The Ohio State University`s James Cancer Hospital and Solove Research Institute and Comprehensive Cancer Center performs 50 DNA tests in one pass to find the best cancer drugs for lung cancer patients. Since lung cancer is often diagnosed in later stages, finding effective therapies quickly is important. See how the technology works here: bit.ly/197VZxB
/newmedia/mcp/osunch/2013/nov13/lungcancer/8-Images/1-Photos/05_Ray_pill.jpg
Managing lung cancer by simply taking a pill.
Raymond Thomas of Delaware, Ohio, manages his lung cancer by simply taking a pill twice a day. Doctors determined which medicine would work best for Thomas by scanning his DNA and spotting genetic mutations that are vulnerable to this medication. The technology is changing the way doctors approach lung cancer cases at The Ohio State University`s James Cancer Hospital and Solove Research Institute and Comprehensive Cancer Center. Details on this individualized approach to care here: bit.ly/197VZxB
/newmedia/mcp/osunch/2013/nov13/lungcancer/8-Images/1-Photos/06_Ray_players.jpg
A revolutionary game plan for tackling lung cancer.
Raymond Thomas, a high school football coach in Ohio, is being treated for lung cancer at The Ohio State University`s James Cancer Hospital and Solove Research Institute and Comprehensive Cancer Center. Within days of being diagnosed with stage 4 lung cancer, Thomas`s DNA was analyzed by a high-tech machine and doctors matched his genetic code with the medicine that will work best for his type of cancer. To see this remarkable technology in action, click here: bit.ly/197VZxB
/newmedia/mcp/osunch/2013/nov13/lungcancer/8-Images/1-Photos/07_Ray_coaching.jpg
Coach refuses to be sidelined by lung cancer diagnosis.
Despite being diagnosed with stage 4 lung cancer, Raymond Thomas continues to coach high school football in Ohio. Thomas` lung cancer is under control, thanks to a high-tech DNA scan performed by doctors at The Ohio State University`s James Cancer Hospital and Solove Research Institute and Comprehensive Cancer Center. After analyzing Thomas` DNA, doctors were able to quickly determine which medicines would work best for him. His story and more on this remarkable technology here: bit.ly/197VZxB
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Using DNA testing to match lung cancer patients with the medicine that will work best for them.
Weiquang Zhao, MD, PhD, analyzes the results of a DNA test at The Ohio State University`s James Cancer Hospital and Solove Research Institute and Comprehensive Cancer Center. Researchers here are using a high-tech machine to perform 50 DNA tests in one pass to help them determine which drugs will work best for lung cancer patients and which drugs to avoid. Details here: bit.ly/197VZxB
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Ohio State University's Comprehensive Cancer Center - James Cancer Hospital & Solove Research Institute
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