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.@OSUWexMed is part of a national #asthma study to better control the disease and costs. Details:  
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Dr. John Mastronarde

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Are You Taking Too Much Asthma Medicine?

Study is underway to find better ways to control both the disease and its costs

(COLUMBUS, Ohio) January 2014 – A national study is underway to better understand how to help asthma patients cut down on their medications, when appropriate, while controlling the disease and its costs.

Between medication, lost productivity and time off from school, asthma costs $56 billion dollars a year in the US - that’s $150 million every day.

“We need to find a way to help patients control their asthma without over-medicating them,” said John Mastronarde, MD, who is leading the study at The Ohio State University Wexner Medical Center.  “The problem is, someone has an asthma attack, their doctor boosts their medication to control it, and in many cases, the patient is never weaned back down,” said Mastronarde.

Ultimately, that strategy can lead to more problems.  Higher doses of medicine can carry long-term side effects and can cost up to $500 per month, creating “a real hurdle for people to stay compliant and take their medication every day,” said Mastronarde.

Doctors will follow 450 patients for nearly a year at 18 research centers across the country to determine which drugs should be given at what dose and for how long.  To learn more about the study click on the video box to the left.  To read the press release, “click to read more” below.









COLUMBUS, Ohio – Asthma researchers at The Ohio State University Wexner Medical Center are part of a national study to establish guidelines for safely stepping down treatment in patients whose asthma is well-controlled.

“Right now, the recommendation is to reduce a patient’s therapy once the asthma is controlled for at least three months. However, no one knows the best method to do that,” said Dr. John Mastronarde, director of the Asthma Center at Ohio State’s Wexner Medical Center. “From both the physician’s and patient’s perspective, there is often hesitation to adjust medication when someone is doing well, so we need good data to support these decisions.”

Asthma therapy typically includes a combination of inhaled corticosteroids to reduce inflammation and mucus in the lungs, and long-acting beta agonists (LABA) that relax and open the airways. Both medications can cause side effects and, in 2006, the U.S. Food and Drug Administration (FDA) issued a public health advisory to caution about risks associated with using LABAs without inhaled corticosteroids. The FDA recommends LABAs be used for the shortest time needed to control asthma symptoms, and be discontinued if possible.

The study is seeking 450 participants from 18 Asthma Clinical Research Centers across the country. People with moderate asthma who enroll in the study will receive combination therapy with fluticasone/salmeterol (Advair) 250/50 mcg twice a day for eight weeks. Participants who are well-controlled and show no symptoms will then be randomized to one of three study arms for 48 weeks. The first group will step down to combination therapy with a 50 percent reduction in the dose of inhaled corticosteroid, fluticasone/salmeterol 100/50 mcg twice a day. The second group will take fluticasone 250 mcg twice per day, eliminating the long-acting beta agonist, salmeterol. The third group will maintain the original dose.

“A few smaller, shorter studies have shown stepping down the inhaled corticosteroid and maintaining the LABA dose is more effective at controlling asthma and lung function, but we need better evidence,” Mastronarde said.

The Centers for Disease Control reports the number of people with asthma has grown 15 percent in the last decade. More than 25 million Americans have asthma, costing the U.S. $56 billion per year.

“Anything we can do to help reduce the medications and, therefore, the side effects and costs associated, will help improve care and quality of life,” Mastronarde said.

GlaxoSmithKline is supplying the drug and financial support for the study, in collaboration with the American Lung Association.

Contact Ohio State’s Asthma Clinical Research Center at 614-293-4978 or





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Asthma takes a heavy toll on patients` bodies and wallets
Dr. John Mastronarde, an asthma physician at The Ohio State University Wexner Medical Center, listens to a patient`s breath sounds. Mastronarde says that many asthma patients are taking more medications than are necessary to control their asthma symptoms - and paying for treatments that they may not need. Nearly 26 million people have asthma in the United States. Between medicine and the time taken off work and school, the disease costs nearly 150 million dollars a day in the US. To learn more about what experts are doing to help eliminate the high cost of asthma, click here:
A new study is underway to try to control asthma and its costs
Dr. John Mastronarde, an asthma physician at The Ohio State University Wexner Medical Center, is leading a study to try to find ways to better control asthma and the costs associated with the disease. Nearly 26 million people have asthma in the United States, at a cost of nearly 150 million dollars a day. Details on how this study hopes to lower the cost of asthma here:
Asthma patients are often prescribed a number of medications
Mary Herrick uses her prescribed inhaler while at work. Mary is taking part in a study from The Ohio State University Wexner Medical Center that is trying to find ways to better wean patients off of medications they do not need and control the costs associated with the disease. As a respiratory therapist herself, Mary worries about how much medicine she really needs to control her asthma. Details here:
Outdoor air is no longer a threat to Mary Herrick
Mary Herrick has always had to pre-medicate before going outside in order to control her asthma. Mary says that her asthma symptoms have stabilized with just one medication since becoming a participant in a new study at The Ohio State University Wexner Medical Center. The goal of the study is to wean participants off of those asthma treatments that they can do without while keeping their asthma - and their wallets - in check. Doctors discuss the study and the high cost of asthma here:
The Ohio State University Wexner Medical Center
The Ohio State University Wexner Medical Center